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What is human papillomavirus? | BY HEIDI


In the United States, around 79 millionTrusted Source people have HPV, and doctors diagnose around 14 million new cases every year.

There are different types of HPV, and some can increase the risk of cancer. Each year, around 19,400 females and 12,100 males in the U.S. develop cancers that stem from HPV.

In this article, learn what HPV is, how it spreads, the symptoms it causes, and their treatments. We also explore HPV vaccines and other ways to protect against the infection.


However, a person can take various steps to remove the warts that HPV can cause. It is also worth noting that these warts often go away without treatment.

Common warts

Over-the-counter salicylic acid products can treat common warts. Do not use these products on warts in the genital area, however.

For some people, a doctor may prescribe one of the following medications:

imiquimod (Aldara, Zyclara)

podofilox (Condylox)

trichloroacetic acid


Also, surgical intervention may be necessary.

A person can purchase treatments for common warts online.

Genital warts

Do not use over-the-counter products on genital warts. A doctor may recommendTrusted Source:

Cryotherapy: This involves using liquid nitrogen to freeze off warts.

Electrocautery: This involves using an electrical current to burn away the warts.

Laser or light therapy: This involves using a high-powered, targeted beam to remove the unwanted tissue.

Surgical removal: A surgeon can cut away warts in an outpatient procedure that involves a local anesthetic.

The best option will depend upon the type and location of the wart. Treatments can remove warts, but the virus will remain in the body and remain transmissible.


Symptoms of HPV may appear years after the initial infection. Some types of the virus cause warts to form, while others can increase the risk of cancer. Specifically, HPV can cause:

Genital warts

large or small

flat or cauliflower-shaped

white, pink, red, purplish-brown, or skin-colored

They can form on the:



penis or scrotum


groin area

These warts can cause itching, burning, and other discomfort.

Other types of warts

HPV can also cause common warts, plantar warts, and flat warts.

Common warts are rough, raised bumps that tend to form on the hands, fingers, and elbows.

Plantar warts are hard, grainy growths that often form on the feet, usually on the heels or balls of the feet.

Flat warts, meanwhile, are flat-topped, slightly raised lesions that are darker than the surrounding skin and often appear on the face or neck.

How HPV can lead to cancer

Most people with HPV do not develop cancer, but the infection can increase the riskTrusted Source, especially in people with weakened immune systems.

A high-risk strain of HPV can change the way that cells communicate with each other, and this can cause them to grow in an uncontrolled way.

In many people, the immune system defeats the unwanted cells. However, if the immune system is unable to do this, the cells can stay in the body and continue to grow. In time, this can lead to cancer.

In the U.S., around 3% of all cancers in females and 2% of all cancers in males stem from HPV.

The infection can increase the risk of developing cancer of the:






oropharynx, includng the base of the tongue and the tonsils

Routine screening can lead to an early diagnosis, and receiving prompt treatment can prevent the cancer from spreading.

The best course of treatment will depend on the type of cancer, its stage, and the age and overall health of the person.


HPV is a virus that transmits through skin-to-skin contactTrusted Source, often sexual contact. The infection can develop in anyone who is sexually active.

There may be no symptoms, or the symptoms may appear and disappear. HPV can passTrusted Source from person to person regardless of whether symptoms are present.

The strains of HPV that cause warts are different from those that increase the risk of cancer.

In children

HPV can transmit to an infant during birth. However, researchTrusted Source suggests that this risk is relatively low, as the immune system usually takes care of the infection in this situation.

If a young child develops HPV symptoms, it may indicate child sexual abuse.

Risk factors

Factors that increase the riskTrusted Source of HPV include:

having several sexual partners

having sex with someone who has had several sexual partners

having sex without using barrier protection, such as a condom or dental dam

having areas of broken or damagedTrusted Source skin

having contact with warts or surfaces where HPV exposure has occurred

not having the HPV vaccination

The risk of cancerTrusted Source is higher if a person has HPV and:

has other sexually transmitted infections, such as chlamydia

delivered their first baby at a young age

has given birth to many children

smokes tobacco products

has a weakened immune system


If warts or lesions are visible, a doctor can usually diagnose HPV with a visual examination. Also, tests can confirm the presence of the virus.

When to get tested for HPV?

a Pap smear

a DNA test

a biopsy

A Pap smear, also called a cervical smear, involves collecting and testing cells from the surface of the cervix or vagina. It can reveal any cellular abnormalities that may lead to cancer.

A DNA test can evaluate for high-risk types of HPV, and a doctor may use it alongside a Pap smear.

A biopsy, which involves taking a sample of affected skin, may be necessary if a test reveals unusual cell changes.

There is currently no routine screening for HPV in males, and the range of testing options is limited. Some experts have called for more testing, especially for men who have sex with men.

How does HPV specifically affect males?

If a person has receptive anal sex, a doctor may recommend an anal Pap smear.

A person can also test for HPV at home, but it is important to see a doctor to confirm the diagnosis. The home test cannot detect cancer.

Home HPV kits are available for purchase online.


Get the HPV vaccine.

Use barrier protection every time they have sex.

Limit their number of sexual partners.

Not have sex while genital warts are present.

To help prevent the warts from spreading:

Avoid touching the wart unnecessarily.

Wash the hands after touching a wart.

Avoid shaving over a wart.

Use footwear in public areas, such as pools and locker rooms, if warts are present on the feet.

Treat and cover a wart until it disappears.

Avoid sharing towels and other personal items.


The Centers for Disease Control and Prevention (CDC)Trusted Source recommend vaccination at the age of 11–12 years to reduce the risk of cervical and other forms of cancer.